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First-thinning harvesting alternatives for industrial or energy purposes based on regional Scots pine stand simulations in Finland. Karttunen K. Silva Fennica vol. Combining research into forest management stand conditions and wood supply chain processes has been missing from earlier forestry studies. There is a clear need to develop more cost-efficient small-diameter wood production, harvesting and transportation methods from first thinning, which could be used for either industrial or energy wood purposes.
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Direct, IC 50 -shift, and time-dependent inhibition were assessed with human liver microsomes. In direct inhibition experiments, imatinib and N-desmethylimatinib inhibited amodiaquine N-deethylation with a K i of 8. Imatinib is a potent mechanism-based inhibitor of CYP3A4 in vitro and this finding explains the imatinib—simvastatin interaction and suggests that imatinib could markedly increase plasma concentrations of other CYP3A4 substrates. Our results also suggest a possibility of autoinhibition of CYP3A4-mediated imatinib metabolism leading to a less significant role for CYP3A4 in imatinib biotransformation in vivo than previously proposed. Imatinib Gleevec, Glivec is the first rationally designed tyrosine kinase inhibitor approved for clinical use, and it has revolutionized the treatment of chronic myelogenous leukaemia CML , advanced gastrointestinal stromal tumours GIST and other haematological and oncological diseases Kovacsovics and Maziarz, ; Duffaud and Le Cesne, ; Stegmeier et al. Imatinib is mainly eliminated via biliary-faecal excretion as unchanged drug and metabolites Food and Drug Administration, ; Gschwind et al. Imatinib has numerous minor metabolites, including both oxidative metabolites and their N- or O-glucuronides.
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